Synthetic bioadhesive

Details Synthetic bioadhesive Synthetic bioadhesive

1990-12-14

1993-03-30

Pellegrino, Stephen C.

Surgery

Instruments

Sutureless closure

128898, 156328, A61B 1708

Patent

active

051979730

ABSTRACT:
This invention pertains to a synthetic adhesive composition for use in aqueous environments. The composition comprises polypeptide chains having an .alpha.-helical structure in aqueous environments and capable of cohesive and adhesive interactions. The polypeptide chains comprise polar and apolar amino acids, the apolar and polar amino acids being arranged to define apolar and polar vertical spiraling stripes on the helix surface. The apolar stripes allow the polypeptide chains to aggregate into superhelical structures and the polar stripes allow interchain crosslinking within and between the superhelical structures.

REFERENCES:
patent: 3759264 (1973-09-01), Coover, Jr.; et al.
patent: 4687740 (1987-08-01), Waite
patent: 4808702 (1989-02-01), Waite
patent: 5015677 (1991-05-01), Benedict et al.
Crick, F. H. C., Acta Cryst (1953); "The Packing of A-Helices: Simple Coiled-Coils".
Dickerson et al., W. A. Benjamin Co., Inc., Menlo Park, Calif; (1969) "The Structure and Action of Proteins".
Parry et al., J. Mol. Biol. (1977); "Structure of A-Keratin: Structure Implication . . . ".
Waite et al., Biochem. & Biophys. Res. Comm., vol. 96, No. 4, pp. 1554-1561; "The Bioadhesive of Mytilus Byssus: . . . ".
Wilson et al.; MacMillan Journals, Ltd. (1981); "Sructure of the Hamemagglutinin Membrane . . . ".
Waite et al., Biochemistry 24:5010-5014 (1985); "Peptide Repeats in a Mussel Glue Protein: Theme . . . ".
Marumo et al., Elsevier Sci. Pub. B.V. (Biomed. Div) (1986); "Optimization of Hydroxylation of Tyrosine and . . . ".
Waite, J. H., J. of Comp. Phys., Comp. Physol. B (1986) 156:491-496; "Mussel Glue from Mytilus Californianus . . . ".
Shoemaker et al., Nature, vol. 326, No. 6113, pp. 563-567 (1987); "Test of the Helix Dipole Model for . . . ".
Jensen et al., J. Comp. Physiol B 158:317-324 (1988); "The Bioadhesive of Phragmatopoma Californica . . . ".
Robin et al., Arch Ophthalmol, vol. 106 (1988); "Preliminary Evaluation of the Use of Mussel . . . ".
Regan et al., Science, vol. 241 (1988); "Characterizations of a Helical Protein Designed from First Principles":
Swerdloff eg al., Int. J. Peptide Protein Res. 33:318-327 (1989); "Solid Phase Synthesis of Bioadhesive Analogue Peptides . . . ".
Williams et al., Archives of Biochem. & Biophys. vol. 269, No. 2, pp. 415-422 (1989); "Mussel Glue Protein has an . . . ".
Trumbore et al., Biophys. Jo. vol. 55 (1989) (abstract); "Investigations of the Structure of the Adhesive . . . ".
Cohen et al., Proteins: Structure, Function & Genetics 7:1-15 (1990); "A-Helical Coiled Coils and Bundles: How to . . . ".

Affiliated with

Also associated with

Rating

Synthetic bioadhesive does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Synthetic bioadhesive, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Synthetic bioadhesive will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1278067