Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Radical -xh acid – or anhydride – acid halide or salt thereof...
Reexamination Certificate
2004-12-13
2011-10-25
Naff, David (Department: 1657)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Radical -xh acid, or anhydride, acid halide or salt thereof...
C424S094100, C424S094500, C435S177000, C514S001100, C514S570000, C530S402000, C530S812000, C548S245000, C562S466000
Reexamination Certificate
active
08044099
ABSTRACT:
Bifunctional molecules and methods for their use are provided. The subject bifunctional molecules are conjugates of a drug moiety and a pharmacokinetic modulating moiety, where these two moieties are optionally joined by a linking group. The bifunctional molecules are further characterized in that they exhibit at least one modulated pharmacokinetic property upon administration to a host as compared to a free drug control. The subject bifunctional molecules find use in a variety of therapeutic applications.
REFERENCES:
patent: 4277501 (1981-07-01), Molloy et al.
patent: 4587046 (1986-05-01), Goodman et al.
patent: 5260066 (1993-11-01), Wood et al.
patent: 5382657 (1995-01-01), Karasiewicz et al.
patent: 5714142 (1998-02-01), Blaney et al.
patent: 5830462 (1998-11-01), Crabtree et al.
patent: 5834266 (1998-11-01), Crabtree et al.
patent: 5840733 (1998-11-01), Krantz et al.
patent: 5843440 (1998-12-01), Pouletty et al.
patent: 5869337 (1999-02-01), Crabtree et al.
patent: 5871753 (1999-02-01), Crabtree et al.
patent: 6043273 (2000-03-01), Duhaylongsod
patent: 6143037 (2000-11-01), Goldstein et al.
patent: 6372712 (2002-04-01), Briesewitz et al.
patent: 6670348 (2003-12-01), Rosen et al.
patent: 6921531 (2005-07-01), Briesewitz et al.
patent: 2002/0045570 (2002-04-01), Rosen et al.
patent: WO 91/01743 (1991-02-01), None
patent: WO 94/18317 (1994-08-01), None
patent: WO 95/02684 (1995-01-01), None
patent: WO 95/05389 (1995-02-01), None
patent: WO 95/10302 (1995-04-01), None
patent: WO 96/06111 (1996-02-01), None
patent: WO 96/12796 (1996-05-01), None
patent: WO 96/13613 (1996-05-01), None
patent: WO 97/25074 (1997-07-01), None
patent: WO 97/29372 (1997-08-01), None
patent: WO 98/00171 (1998-01-01), None
patent: WO 98/11437 (1998-03-01), None
patent: WO 98/46270 (1998-10-01), None
patent: WO 98/47002 (1998-10-01), None
patent: WO 98/47916 (1998-10-01), None
patent: WO 99/12570 (1999-03-01), None
Karra et al. Tc-labeling and in Vivo Studies of a Bombesin Analogue with a Novel Water-Soluble Dithiadiphosphine-Based Bifunctional Chelating Agent. Bioconjugate Chem. 1999, 10, 254-260.
Toth et al. A Novel Chemical Approach to Drug Delivery: Lipidic Amino Acid Conjugates. Journal of Drug Targeting. Switzerland, 1994, vol. 2, No. 3, pp. 217-239.
Database Biosis [Online] Biosciences Information Service-Philadelphia, PA, US; 1995 SNEL C A Wilco et al. Disposition of thebromosulfophthalein-glutathione conjugate in the isolated perfused rat kidney—Database accession No. PREV 199598364814 XP002220714—Journal of Pharmmacology and Experimental Therapeutics, vol. 273, No. 3, 1995, pp. 1300-1306.
Database Biosis [Online] Biosciences Information Service-Philadelphia, PA, US; 1992, Hayball P J et al. “Stereoselective Interactions of Ketoprofen with Human Plasma Protein and Serum Albumin”, Database accession No. prev199294111953 XP002220709 & Biochemical Pharm. vol. 44, No. 2, 1992, pp. 291-299.
Srinivasa R. Karra et al. “99m Tc-Labeling and in Vivo Studies of a Bombesin Analogue with a Novel Water—Soluble Dithiadiphosphine-Based Bifunctional Chelating Agent”Bioconjgate Chem. 1999, 10, 254-260.
Snel C.A. Wilco et al. Database Biosis Online—Biosciences Information Service, Database Accession No. PREV199598364814 XP-002220714 “Disposition of the bromosulfophthalein-gluthatione conjugate in the isolated perfused rat kidney” (1995) AbstractJournal of Pharmacology and Experimental Therapeutics, vol. 273, No. 3, 1995 (pp. 1300-1306, ISSN:0022-3565.
P.J. Hayball et al. Database Biosis Online—Biosciences Information Service, Database Accession No. 199294111953 XP002220709 “Stereoselective Interactions of Ketoprofen Glucuronides with Human Plasma Protein and Serum Albumin” AbstractBiochemical Pharmacology, vol. 44, No. 2, 1992 pp. 291-299, ISSN:0006-2952.
I. Toth “A Novel Chemical Approach to Drug Delivery: Lipid Amino Acid Conjugates”Journal of Drug Targeting, Switzerland 1994, vol. 2, No. 3, pp. 217-239.
Kudak et al. “Synthesis and Evaluation of Geldanamycin-Testosterone Hybrids” Bioorg—Med. Chem., Lett. 10 (2000) 1303-1306.
Al-Obeidi, et al., (1990) “Synthesis and Actions of a Melanotropin Conjugate, Ac-[Nle4, Glu(gamma-41-hydroxyanilide)5, D-Phe7]α -MSH4-10-NH2, on Melanocytes and Melanoma Cells in Vitro,”Journal of Pharmaceutical Sciencesvol. 79, No. (6):500-504.
Atwell, John L., et al., (1996) ADesign and Expression of a Stable Bispecific scFv Dimer With Affinity for Both Glycophorin and N9 Neuraminidase,@Molecular Immunologyvol. 22, No. (17/18):1301-1312.
Belshaw, et al., (1996) “Controlling Protein Association and Subcellular Localization with a Synthetic Ligand that Induces Heterodimerization of Proteins,”Proc. Natl. Acad. Sci. U.S.A. vol. 93:4604-4607.
Bernstein, Kenneth E., et al., (1990) AA Deeply Recessed Active Site in Angiotensin-Converting Enzyme is Indicated From the Binding Characteristics of Biotin-Spacer-Inhibitor Reagents,@Biochemical and Biophysical Communicationsvol. 167, No. (1):310-316.
Bourdouxhe-Housiaux, Catherine, et al., (1996) Alnteraction of DNA-Threading Peptide-Amsacrine Conjugates With DNA and Chromatin,@Anti-Cancer Drug Designvol. 11:509-525.
Brochu, et al., (1992) “Modes of Action and Inhibitory Activities of New Siderophore-β-Lactam Conjugates that use Specific Iron Uptake Pathways for Entry into Bacteria,”Antimicrobial Agents and Chemotherapyvol. 36, No. (10):2166-2175.
Briesewitz, et al., (1999) “Affinity Modulation of Small-Molecule Ligands by Borrowing Endogenous Protein Surfaces,”P.N.A.Svol. 96, No. (5):1953-1958.
Chakraborty, TK., et al., (1995) ADesign and Synthesis of a Rapamycin-Based High Affinity Binding FKBP12 Ligand,@Chemistry & Biologyvol. 2:157-161.
Crabtree, Gerald R., et al., (1996) AThree-Part Inventions: Intracellular Signalling and Induced Proximity,@Elsevier Trends Journalpp. 418-422.
Heath, et al., (1986) “Liposome-Mediated Delivery of Pteridine Antifolates to cells in Vitro: Potency of Methotrexate, and its α and γ Substituents,”Biochimica et Biophysica Actavol. 862:72-80.
Ho, Steffan N., et al., (1996) ADimeric Ligands Define a Role for Transcriptional Activation Domains in Reinitiation,@Nature, vol. 382, No. (6594):822-826.
Holt, et al., (1994) “Structure-Activity Studies of Synthetic FKBP Ligands as Peptidyl-Prolyl Isomerase Inhibitors,”Bioorganic and Medicinal Chemistry Lettersvol. 4, No. (2):315-320.
Kramer, Werner, et al., (1992) ALiver-Specific Drug Targeting by Coupling to Bile Acids,@The Journal of Biological Chemistry, vol. 267, No. (2):18598-18604.
Luengo, et al., (1994) “Synthesis and Structure-Activity Relationships of Macrocyclic FKBP Ligands,”Bioorganic and Medicinal Chemistry Lettersvol. 4, No. (2):321-324.
Lussow, et al., (1996) “Targeting of Antihapten Antibodies to Activated T Cells via an IL-2-Hapten Conjugate Prolongs Cardiac Graft Survival,”Trasplantationvol. 62, No. (12):1703-1708.
Maeda, et al., (1997) “Amino Acids and Peptides XXXII: A Biofunctional Poly(Ethylene Glycol) Hybrid of Fibronectin-Related Peptides,”Biochemical and Biophysical Research Communicationsvol. 241:595-598.
Mogre, R.M., et al., (1987) AA New Carbene Based Heterbifunctional Reagent: Photochemical Crosslinking of Aldolase,@FEBS Letters, vol. 221, No. (2):408-414.
Mu, Yu., et al., (1999) ABioconjugation of Laminin Peptide YIGSR With Poly(Styrene Co-Maleic Acid) Increases its Antimetastatic Effect on Lung Metastasis of B16-BL6 Melanoma Cells,@Biochemical and Biophysical Research Communications, vol. 255:75-79.
Varshaysky, Alexander, (1998) ACodominant Interference, Antieffectors, and Multitarget Drugs,@Proc. Natl. Acad. Sci. USA, vol. 95:2094-2099.
Varshaysky, Alexander, (1995) ACodominance and Toxins: A Path to Drugs of Neatly Unlimited Selectivity,@Proc. Natl. Acad. Sci. USA, vol. 92:3663-3667.
Zunino, et al., (1984) “Compassion of Antitumor Effects of Daunorubicin Coval
Briesewitz Roger
Crabtree Gerald R.
Wandless Thomas J.
Bozicevic Field & Francis LLP
Field Bret E.
Naff David
The Board of Trustees of the Leland Stanford Junior University
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