Synthetic antisense oligodeoxynucleotides targeted to human ache

Details Synthetic antisense oligodeoxynucleotides targeted to human ache Synthetic antisense oligodeoxynucleotides targeted to human ache

1997-12-12

2000-09-19

LeGuyader, John L.

Chemistry: molecular biology and microbiology

Animal cell, per se ; composition thereof; process of...

Method of regulating cell metabolism or physiology

435 6, 435 911, 435325, 435354, 435455, 536 231, 536 2431, 536 2433, 536 245, 514 44, C07H 2104, C12Q 168, C12N 1500

Patent

active

061210463

ABSTRACT:
A synthetic nuclease resistant antisense oligodeoxynucleotide (AS-ODN) capable of selectively modulating human acetylcholinesterase (AChE) production and a composition comprising at least one AS-ODN as an active ingredient. A nuclease resistant antisense targeted against the splice junction in the AChE mRNA post-splice message is disclosed. The synthetic nuclease resistant AS-ODNs are capable of selectively modulating human AChE production in the central nervous system or capable of selectively reducing human AChE deposition of the neuromuscular junction. The present invention also provides a method to restore balanced cholinergic signalling in the brain and spinal cord or reduce AChE in the neuromuscular junction in patients in need of such treatment by administering to a patient in need of such treatment a therapeutically effective amount of at least one of the synthetic nuclease resistant AS-ODN capable of selectively modulating human AChE production.

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