Synthetic antimicrobial peptide

Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues

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Details

530324, 530350, 514 2, A61K 3800, C07K 1400

Patent

active

058309934

ABSTRACT:
New antimicrobial truncated peptides are disclosed which are based upon a known peptide, PR-39 (SEQ ID NO: 1) but which contain a lesser number of amino acid residues yet still retain antimicrobial activity. The most preferred peptide compound is PR-26, SEQ ID NO: 2. The invention also relates to a method of inhibiting microbial growth by administering an effective amount of a peptide in accordance with the invention.

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patent: 5206154 (1993-04-01), Lai et al.
patent: 5324716 (1994-06-01), Selsted et al.
Shi, et al.; Identification of a Proline-Arginine-Rich Antibacterial Peptide from Neutrophils that is Analogus to PR-39, an Antibacterial Peptide from the Small Intestine; Journal of Leukocyte Biology; vol. 56, No. 6, Dec. 1994, pp. 807-811.
Agerberth et al.; Amino Acid Sequence of PR-39; Eur. J. Biochecm. 202, 849-854.

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