Synthetic antigens for the detection of antibodies to hepatitis

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving virus or bacteriophage

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435 792, 435 795, 436518, 436820, 530326, G01N 33576, C12Q 170

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059104040

ABSTRACT:
Peptide sequences are provided which are capable of mimicking proteins encoded by HCV for use as reagents for screening of blood and blood products for prior exposure to HCV. The peptides are at least 5 amino acids long and can be used in various specific assays for the detection of antibodies to HCV, for the detection of HCV antigens, or as immunogens.

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Kuo, G., et al, Science, 244 : 362-364 (1989) "An Assay for Circulating Antibodies to a Major Etiologic Virus of Human Non-A, Non-B Hepatitis".
Okamoto, H., et al, Japan J. Exp. Med., 60:3 167-177 (1990) "The 5'-Terminal Sequence of the Hepatitis C Virus Genome".
Okamoto, H., et al, Japan J. Exp. Med., 60:4 223-233 (1990) "Enzyme-Linked Immunosorbent Assay for Antibodies against the Capsid Protein of Hepatitis C Virus with a Synthetic Oligopeptide".
Viancks, R., Eur. J. Clin. Microbiol. Infect. Dis., 9(9), 1990 "Evaluation of a line immunoassay for the differential detection of antibodies to human immunodeficiency virus", 674-676.
Shimonishi, Y., Ed. Peptide Chemistry, 1990 "Proceedings of the 26th Symposium on Peptide Chemistry", Osaka, Oct. 25-27, 1990.
Munekata et al, "Epitope-Mapping of Hepatitis C Virus Constituting Protein" pp. 211-214, Protein Research Foundation, Osaka, 1991.

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