Synthetic anti-inflammatory derivatives of manoalide

Details Synthetic anti-inflammatory derivatives of manoalide Synthetic anti-inflammatory derivatives of manoalide

1984-06-18

1986-10-07

Milestone, Norma S.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

549294, 549318, 514461, C07D30758

Patent

active

046160892

ABSTRACT:
Synthetic analogs of the marine natural product manoalide include 3,7-Bis(hydroxymethyl)-4-hydroxy-11-methyl-13-(2',6',6'-trimethylcyclohexe nyl)-2,6,10-tridecatrienoic acid .gamma.-lactone, manoalide .delta.-lactone, manoalide .delta.-lactone acetate and dehydro-seco-manoalide.
The method of treating mammals including humans in need of a drug having analgesic and/or anti-inflammatory activity comprising the administration of a therapeutically effective amount of a synthetic analog of manoalide.

REFERENCES:
patent: 4447445 (1984-05-01), Jacobs et al.

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