Synthetic antagonists based on angiotensin

Details Synthetic antagonists based on angiotensin Synthetic antagonists based on angiotensin

1997-05-06

2000-05-09

Gupta, Yogendra N.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

5483425, C07D25704

Patent

active

060606037

ABSTRACT:
Disclosed are methods for modelling the three-dimensional structure (tertiary structure) of a ligand having one or more active sites employing a charge-transfer interaction. Also disclosed is a model for Angiotensin II derived from such method.

REFERENCES:
patent: 3386026 (1968-05-01), Ponpipom et al.
patent: 4355040 (1982-10-01), Furukawa et al.
patent: 4485177 (1984-11-01), Siedel et al.
patent: 4578361 (1986-03-01), Siedel et al.
patent: 4702864 (1987-10-01), Magolda et al.
patent: 4818684 (1989-04-01), Edelman et al.
patent: 4818763 (1989-04-01), Rusch et al.
patent: 4830961 (1989-05-01), Petty
patent: 4845075 (1989-07-01), Murray et al.
patent: 4845132 (1989-07-01), Masuoka et al.
patent: 4849407 (1989-07-01), Murray et al.
patent: 4853871 (1989-08-01), Pantoliano et al.
patent: 5015651 (1991-05-01), Carini et al.
patent: 5073566 (1991-12-01), Lifer et al.
patent: 5151435 (1992-09-01), Bagley et al.
patent: 5153197 (1992-10-01), Carini et al.
patent: 5177095 (1993-01-01), Greenlee et al.
Moore, G. et al, "Structure-desensitization relationships of angiotensin . . . ", Can. J. Physiol. Pharmacol, vol. 63 (1985), pp. 966-971.
Davidson, D. et al, "The Action of Ammonia on Benzil", The J. of Organic Chemistry, vol. 2, No. 1, pp. 319-327, (1937).
Goghari, M. et al, "Structure-Activity Relationships for the Competitive . . . ", Journal of Medicinal Chemistry, vol. 29, No. 6, (1986), pp. 1121-1124.
Matsoukas, J. et al, "Synthesis and Biological Activities of Analogues . . . ", Journal of Medicinal Chemistry, vol. 28, No. 6, (1985), pp. 780-783.
Wong, P. et al, "Nonpeptide Angiotensin II Receptor Antagonist. IV. EXP6155 and EXP6803", Hypertension, vol. 13, No. 5, (May 1989), pp. 489-497.
Kessler, H. et al, "Separation of Cross-Relaxation and J Cross-Peaks . . . ", Journal of American Chemical Society, vol. 109, No. 2, (1987), pp. 607-609.
Moore, G. et al, "Synthesis of Angiotensin II Antagonist . . . ", Journal of Medicinal Chemistry, vol. 22, No. 9 (1979), pp. 1147-1149.
Scanlon, M. et al, "A New Approach to Angiotensin Antagonist: . . . ", Life Sciences, vol. 34, No. 4 (1984), pp. 317-321.
Moore, G. et al, "Angiotensin as a model for hormone-receptor interactions", Bioscience Reports, vol. 5 (1985), pp. 407-416.
Matsoukas, J. et al, "Proton Magnetic Resonance Studies of Angiotensin II . . . ", Archives of Biochemistry and Biophysics, vol. 248, No. 1 (1986), pp. 419-423.
Rauk, A. et al, "Mechanistic Consequences of Charge Transfer Systems . . . ", Biochemical and Biophysical Research Communications, vol. 145, No. 3 (1987), pp. 1349-1355.
Matsoukas, J. et al, "NMR and Mass Spectroscopic Studies of the Competitive . . . ", Spectroscopy Letters, vol. 21, No. 5 (1988), pp. 477-491.
Moore, G. et al, "Methods for Analyzing and Interpreting Cooperatively . . . ", General Pharmacology, vol. 20, No. 2 (1989), pp. 193-198.
Moore, G. et al, "Angiotensin, `Antipepties`: (-)Messenger RNA . . . ", Biochemical and Biophysical Research Communications, vol. 160, No. 3 (1989), pp. 1387-1391.
Sargent, D. et al, "Membrane Lipid Phase as Catalyst . . . ", Proc. Natl Acad. Sci., vol. 83, (1986) pp. 5774-5778.
Surewicz, W. et al, "Conformational Properties of Angiotensin II . . . ", J. Amer. Chem. Soc., 110, pp. 4412-4414 (1988).
Cheatham, S., "Nuclear Magnetic Resonance Spectroscopy in Biochemistry", Journal of Chemical Education, vol. 66, pp. 111-117 (1989).
Bax, A., Practical Aspects of Two-Dimensional Transverse NOE Spectroscopy J. of Magn. Reson., vol. 63, pp. 207-213.
Moore, G. et al. "Kinetics of Acetylation-Deacetylation of Angiotensin II", Int. J. Pept. Prot. Res., vol. 26, (1985), pp. 469-481.
Grinvald, A. et al., "On the Analysis of Fluoresence Decay Kinetics by the Method of Least Squares", Anal. Biochem., vol. 59, pp. 583-598 (1974).
Lampert, R. et al., "Standards for Nanosecond Fluorescence Decay Time Measurements", Anal. Chem., vol. 55, pp. 68-73 (1983).
Matsoukas, J. et al., "Importance of the N-Terminal Domain of the Type II . . . ", J. Med. Chem., vol. 31, No. 7, (1988), pp. 1418-1421.
Otter, A. et al, "Type I Collagen .alpha.-1 Chain C-Telopeptide: Solution Structure . . . ", Biochemistry, vol. 27, No. 10, pp. 3560-3567, (1988).
Marion, D. et al, Application of Phase Sensitive Two-Dimensional Correlated Biochem Biophys. Res. Commun., vol. 113, No. 3, pp. 967-974 (1983).
Smeby, R. "Conformation of Angiotensin II", Chemistry and Biochemistry of Amino Acids, Peptides, and Proteins, vol. 5, Dekker, New York, pp. 117-163, (1978).
Matsokas, J. et al, "NMR Studies on Angiotensin II: Histidine and . . . ", Biochemical and Biophysical Research Comm., vol. 122, No. 1, pp. 434-438, (1984).
Moore, G., "Photoaffinity Labelling of Angiotensin Receptors: Functional . . . ", Pharmacol. Ther., vol. 33, pp. 349-381, (1987).
Matsoukas, J. et al, "Proton Magnetic Resonance Studies of . . . ", Peptides 1986, Proc. of the 19th Euorpean Peptide Symp . . ., Ed. D. Theodoropoulos, pp. 335-339.
Heinze, J. et al, Chem. Ber., vol. 101, pp. 3504-3516, (1968).
Hofle, G. et al, "4-Dialkylaminopyridines as Highly Active Acylation Catalysts.sup.[1,2] ", Angew Chem. Int. Ed. Engl., vol. 17, pp. 569-583, (1978).
Otter, A. et al, "Solution Conformation of N-Acetyl-L-prolyl-L-glutaminyl-. . . ", J. Am. Chem. Soc., vol. 109, pp. 6995-7001, (1987).
Fowler, P. et al, "Calculation of the Magnitude and Orientation . . . ", Biochemical and Biophysical Research Comm., vol. 153, No. 3, pp. 1296-1300, (1988).
Stewart, J. et al, Solid Phase Peptide Synthesis, Pierce Chem. Co. (1984).

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