Synthetic analogues of .alpha.-melanotropin

Details Synthetic analogues of .alpha.-melanotropin Synthetic analogues of .alpha.-melanotropin

1982-06-11

1984-11-27

Phillips, Delbert R.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

C07C10352

Patent

active

044850395

ABSTRACT:
Cyclic analogues of the tridecapeptide hormone, .alpha.-melanotropin. (.alpha.-melanocyte stimulating hormone, .alpha.-MSH), wherein a physiologically stable intramolecular interaction exists (1) between the amino acid residue at position 4 and an amino acid residue at position 10 or 11, and/or (2) between the amino acid residue at position 5 and an amino acid residue at position 10 or 11. Preferred analogues, e.g., [half-Cys.sup.4, half-Cys.sup.10 ]-.alpha.-MSH display greatly increased in vitro potency, prolongation, and resistance to enzymatic degradation.

REFERENCES:
Sawyer et al., Proc. Natl. Acad. Sci USA, 79, 1751-1755 (3/1982), Biochemistry.
Chemical Abstracts, 97, 1982, p. 59, Abst.No., 33522(c).
Chemical Abstracts, 90, 1979, p. 102, Abst. No., 16790(b).
Knittel et al., J. Med. Chem., 28, 124-129, (1983).
Barth et al., Inst. of Org. Chem. and Biochem., Czechaslovak Academy of Sciences, 45, 3045-3050, (1980).
Hase et al., J.A.C.S., 94, 3590-3600, (1972).
Swaab et al., Front. Hormone Res., 4, 177-178, (1977).
Shizume et al., Bioassay of MSH, 54, 553-560, (1954).
Hadley et al., A.A.A.S., 213, 1025-1027, (1981).
Salomon et al., Analytical Biochem., 58, 541-548, (1974).
Sawyer et al., Proc. Natl. Acad. Sci., 77, (No. 10), 5754-5758, (1980).
Cellular Receptors for Hormones and Neurotransmitters, John Wiley and Sons Ltd., Chapter 12, (1980).
Yang et al., Int. J. Peptide Protein Res., 15, 130-138, (1980).
Huntington et al., Endocrinalogy, 96(2), 472-479, (1974).
Schwyzer ACTH: Swiss. Fed. Ins. Tech., Zurich, Switzerland Annals of N.Y. Acad. of Sci., pp. 3-26.
Peptides of the Pars Intermedia, Pitman Medical, 244-262, (1981).

Affiliated with

Also associated with

Rating

Synthetic analogues of .alpha.-melanotropin does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Synthetic analogues of .alpha.-melanotropin, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Synthetic analogues of .alpha.-melanotropin will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2133748