Synthetic analogs of bacterial quorum sensors

Details Synthetic analogs of bacterial quorum sensors Synthetic analogs of bacterial quorum sensors

2009-09-01

2011-12-06

Chandrakumar, Nizal (Department: 1625)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C549S321000

Reexamination Certificate

active

08071790

ABSTRACT:
Bacterial quorum-sensing molecule analogs having the following structures:and methods of reducing bacterial pathogenicity, comprising providing a biological system comprising pathogenic bacteria which produce natural quorum-sensing molecule; providing a synthetic bacterial quorum-sensing molecule having the above structures and introducing the synthetic quorum-sensing molecule into the biological system comprising pathogenic bacteria. Further is provided a method of targeted delivery of an antibiotic, comprising providing a synthetic quorum-sensing molecule; chemically linking the synthetic quorum-sensing molecule to an antibiotic to produce a quorum-sensing molecule-antibiotic conjugate; and introducing the conjugate into a biological system comprising pathogenic bacteria susceptible to the antibiotic.

REFERENCES:
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Reimmann et al., “The Global Activator GacA of Pseudomonas Aeruginosa PAO Positively Controls the Production of the Autoinducer N-butyryl-homoserine Lactone and the Formation of the Virulence Factors Pyocyanin, Cyanide, and Lipase”, Molecular Microbiology, 1997, vol. 24, pp. 309-319.
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Ishida et al., Inhibition of Quorum Sensing in Pseudomonas Aeruginosa by N-Acyl Cyclopentylamides, Applied and Environmental Microbiology, May 2007, vol. 73, No. 10, pp. 3183-3188.
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