Synthetic aminoglycosides

Details Synthetic aminoglycosides Synthetic aminoglycosides

1977-06-08

1980-06-17

Brown, Johnnie R.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

424180, 536 4, 536 10, A61K 3171, C07H 1522

Patent

active

042085314

ABSTRACT:
Novel pseudotrisaccharides based on 2-deoxy- and 2,5-dideoxystreptamine are described. The compounds of the invention can be considered as modified Kanamycin, Gentamycin and Apramycin compounds. In particular they are deoxy derivatives especially at the 2', 3', 4', 2", 3" and/or 4" and/or possibly at the 6' or 6" positions. The compounds are active bactericides some of which are more active than Kanamycin. It is a particular advantage of the compounds that they are active against Kanamycin resistant bacteria. Methods of making these compounds are also described based on glycosylation reaction from corresponding monosaccharide compounds.

REFERENCES:
patent: 4029883 (1977-06-01), Hiraga et al.
patent: 4031210 (1977-06-01), Chazan et al.
patent: 4051315 (1977-09-01), Godfrey et al.
patent: 4063015 (1977-12-01), Mallams

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