Synthetic .alpha.-L-iduronidase and genetic sequences encoding s

Details Synthetic .alpha.-L-iduronidase and genetic sequences encoding s Synthetic .alpha.-L-iduronidase and genetic sequences encoding s

1998-11-13

2000-11-21

Wax, Robert A.

Drug, bio-affecting and body treating compositions

Enzyme or coenzyme containing

Hydrolases

435200, A61K 3847, C12N 924

Patent

active

061499099

ABSTRACT:
The present invention relates generally to .alpha.-L-iduronidase and to genetic sequences encoding same. More particularly, the present invention provides an isolated nucleic acid molecule comprising a sequence of nucleotides which encodes or are complementary to a sequence which encodes a mammalian .alpha.-L-iduronidase or fragment or derivative thereof and to the recombinant enzyme encoded thereby. These molecules are useful in the investigation, diagnosis and treatment of subjects suspected of or suffering from .alpha.-L-iduronidase deficiency.

REFERENCES:
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