Synthetic airial peptides

Details Synthetic airial peptides Synthetic airial peptides

1986-03-27

1987-12-29

Philips, Delbert R.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 13, 514 12, 530324, 530325, 530326, A61K 3702, C07K 710, C07K 708

Patent

active

047161477

ABSTRACT:
Novel synthetic atrial peptides are provided with enhanced natriuretic properties by substituting one or two arginine residues for the N-terminal ser-ser in atriopeptins I, II and III and their physiologically acceptable salts, esters and amides.

REFERENCES:
patent: 4496544 (1985-01-01), Needleman
patent: 4508712 (1985-04-01), Needleman
Currie et al., Science 223, 67-69, (1984).
Geller et al., Biochem. Biophys. Res. Commun., 120(2), 333-8, (1984).
Wakitani et al., J. Lab. Clin. Med., 105(3), 349-352, (1985).
Flynn et al., Biochem. Biophys. Res. Commun., 117(3), 859-65, (1983).
Seidah et al., Proc. Natl. Acad. Sci. USA 81, 2640-44, (1984).
Schwartz et al., Science, 229, 397-400, (1985).
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Garcia et al., Ibid., 126(1), 178-184, (1985).
Katsube et al., Ibid., 128(1), 325-30, (1985).
Johnson, Life Sci., 38(3), 225-31, (1985).
Kangawa et al., Biochem. Biophys. Res. Commun., 118(1), 131-139, (1984).

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