Drug – bio-affecting and body treating compositions – Conjugate or complex of monoclonal or polyclonal antibody,... – Conjugated via claimed linking group – bond – chelating agent,...
Patent
1976-08-09
1977-11-15
Brown, Johnnie R.
Drug, bio-affecting and body treating compositions
Conjugate or complex of monoclonal or polyclonal antibody,...
Conjugated via claimed linking group, bond, chelating agent,...
536 23, A61K 3134, A61K 3153, C07H 1912
Patent
active
040586022
ABSTRACT:
The compound 5,6-dihydro-5-azacytidine, 5AC[H], and non-toxic acid addition salts such as the hydrochloride, together with its preparation from 5-azacytidine (5-AC) by reduction of the 5,6-double bond of 5-AC with an alkali metal borohydride such as sodium borohydride. Additionally, 5,6-dihydro-5-azacytidine, 5AC[H], has antitumor activity for murine leukemia systems L1210 and P388 as an injectable. In comparison with the parent compound, 5-AC, the antitumor activity is comparable and 5AC[H] exhibits a more favorable therapeutic index. It also has better solution stability over a broad pH range. A structure for the HCl salt is given below. ##STR1##
REFERENCES:
patent: 3171833 (1965-03-01), Sorm et al.
patent: 3221010 (1965-11-01), Duschinsky
patent: 3462416 (1969-08-01), Hanze et al.
Abbasi Mohamed M.
Beisler John A.
Driscoll John S.
Brown Johnnie R.
Ferris Thomas G.
Latker Norman J.
Roberts, Jr. John S.
The United States of America as represented by the Department of
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