Synthesis procedure for imidazolyl carbinol derivatives such...

Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

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Reexamination Certificate

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07112681

ABSTRACT:
A synthesis procedure for the manufacture of byphenylimidazolyl-(1)-phenylmethane involves the reduction of 4-phenyl-benzophenone and subsequent reaction of biphenyl-phenyl-carbinol with imidazole. In a preferred form, there are two synthesis steps, the first step being the reduction of 4-phenyl-benzophenone to biphenyl-phenyl-carbinol being with sodium borohydride in the presence of alumina, and the second step being the reaction between biphenyl-phenyl-carbinol and imidazole assisted by microwaves, in the absence of any organic or inorganic solvents, obtaining a yield between 70 to 74% of pure product in a total reaction time of no more than three hours.

REFERENCES:
patent: 4118487 (1978-10-01), Regel et al.
patent: 4251540 (1981-02-01), Regel et al.
patent: 6870057 (2005-03-01), Handal Vega et al.
Corelli, F., “Chiral Azole Derivatives. Synthesis of Enantiomerically Pure 1-Alkylimidazoles” J. Org. Chem. vol. 60, pp. 2008-2015 (1995).
Federico Corelli, et al., “Chiral Azole Derivatives. 2. Synthsis of Enantiomerically Pure 1-Alkylimidazoles”, Journal of Organic Chemistry., vol. 60, No. 7, (1995) pp. 2008-2015, XP002189742.

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