Synthesis of VIP analog

Details Synthesis of VIP analog Synthesis of VIP analog

1997-02-07

2000-06-27

Tsang, Cecillia J.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

25 or more amino acid residues in defined sequence

530334, 530338, C07K 110, C07K 1400

Patent

active

060808373

ABSTRACT:
This invention relates to a novel process for the synthesis of vasoactive intestinal peptide analog Ac(1-31)--NH.sub.2 from four protected peptide fragments.

REFERENCES:
patent: 4237046 (1980-12-01), Bodanszky et al.
Chemical Abstracts, vol. 101, No. 19, Nov. 5, 1984, abstract No. 171691.
Paul, et al. J. Biol Chem. Site Specificity of a Catalytic Vasoactive Intestinal Peptide Antibody. 265:11910-11913 (1990).
Remmer et al., `Comparison of FMOC Solid Phase Methods for Teh Synthesis of Pure [Nle 17]-VIP`, Innovation Perspect. Sold Phayse Synth. Collect. Pap. Int. Symp., 3rd (1994), Meedtin date 1993. (Ed. Epton, Roger). Mayflower Worldwide Ltd., Brimingham, UK, 1994.
Jaeger et al., `Structre Activity Studies on VIP. II. Synthesis of Analogs Modified at Position Arg 12, Arg 14-Lys 15, Met 17 and Lys 20-Lys 21, Including a Potent VIP/PHM-Hybrid`, Int.Symp. Vasoact. Intest. Pept., Pituitary Adenylate Cyclase Act. Polypept, 1994.
O'Dennell et al., `Ro 25-1553: A Novel, Long-Acting Vasoactive Intestinal Peptide Agonist. Part 1: In Vitro and In Vivo Brochodilator Studies`, Journal of Pharmacology and Experimental Therapeutics, vol. 270, No. 3, pp. 1282-1288, 1994.

Affiliated with

Also associated with

Rating

Synthesis of VIP analog does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Synthesis of VIP analog, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Synthesis of VIP analog will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1785475