Synthesis of typhoid fever vaccine from a plant or fruit polysac

Details Synthesis of typhoid fever vaccine from a plant or fruit polysac Synthesis of typhoid fever vaccine from a plant or fruit polysac

1994-10-17

1998-04-14

Minnifield, N. M.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

4241841, 4241971, 4242361, 4241921, 536123, 514 2, 514 53, 530402, A61K 3900, A61K 39385, A61K 4500, C07G 1700

Patent

active

057388555

ABSTRACT:
The present invention is a modified plant, fruit or synthetic oligo- or polysaccharide which has been structurally altered so as to render the modified saccharide antigenically similar to the Vi of Salmonella typhi. The modified saccharide may be conjugated to a carrier to form a conjugate that is immunogenic against S. typhi. Antibodies produced in response to the immunogenic conjugate are protective against typhoid fever. Methods are provided for making the modified saccharide and the immunogenic conjugate.

REFERENCES:
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Szu et al, Synthesis and Some Immunologic Properties of an O-Acetyl Pectin Typhoid Fever, Infection and Immunity, Dec. 1994, pp. 5545-5549, vol. 62, No. 12.
Acharya et al, Prevention of Typhoid Fever in Nepal with the Vi Capsular Polysaccharide of Salmonella typhi, New England Journal of Medicine, 317:1101-1105, Oct. 29, 1987. Immunication of Mice with Escherichia coli K92 Conjugates: Potential Vacines for Groups B and C Meningococci and E. coli K1, Proc. Natl. Acad. Sci. vol. 88, pp. 7175-7179, Aug. 1991.
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