Synthesis of triphenylphosphonium quinols and quinones

Details Synthesis of triphenylphosphonium quinols and quinones Synthesis of triphenylphosphonium quinols and quinones

2007-02-20

2007-02-20

Page, Thurman K (Department: 1621)

Organic compounds -- part of the class 532-570 series

Organic compounds

Cyclohexadiene having atoms double bonded directly at the 1-...

C568S009000

Reexamination Certificate

active

10486797

ABSTRACT:
The methods of preparing quinols and quinones typified by mitoquinol and mitoquinone where a compound typified by idebenone is reacted with Ph3PHX and Ph3P, where X is a halogen atom.

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Kelso et al., Selective Targeting of a Redox-active Ubiquinone to Mitochondria within Cells, J. Biol. Chem., Feb. 2001; 276: 4588-4596.
Coulter, C., et al., “Mitochondrially Targeted Antioxidants and Thiol Reagents,”Free Radic Biol Med., 28(10):1547-54, May 15, 2000.
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Kelso, G., et al., “Selective Targeting of a Redo-Active Ubiquinone to Mitochondria within Cells,”J. Biol. Chem., 276(7):4588-4596, Feb. 16, 2001.
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