Synthesis of thienamycin via (3SR, 4RS)-3-((RS)-1-acyloxyethyl)-

Details Synthesis of thienamycin via (3SR, 4RS)-3-((RS)-1-acyloxyethyl)- Synthesis of thienamycin via (3SR, 4RS)-3-((RS)-1-acyloxyethyl)-

1980-01-14

1981-09-01

Berch, Mark L.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

560 19, 560170, 560171, 560145, 542427, 2603435, 2602452T, C07D20508, C07D48704, C07D30930, C07F 710

Patent

active

042871239

ABSTRACT:
Disclosed is a process for the stereocontrolled total synthesis of thienamycin, which synthesis proceeds via intermediate II: ##STR1## wherein R is a readily removable carboxyl protecting group; and ##STR2## is a readily removable acyl group.

REFERENCES:
patent: 3994888 (1976-11-01), Kukolja
patent: 4008229 (1977-02-01), Spitzer
patent: 4008230 (1977-02-01), Koppel
patent: 4122262 (1978-10-01), Buckley et al.

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