Synthesis of terfenadine and derivatives

Details Synthesis of terfenadine and derivatives Synthesis of terfenadine and derivatives

1999-05-24

2000-11-14

Chang, Ceila

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

546236, 546237, 546239, C07D21122, C07D21134

Patent

active

061472174

ABSTRACT:
Processes for preparing compounds having the general formula: ##STR1## wherein R.sup.1a is protected carboxy, carboxy, hydroxymethyl, protected hydroxymethyl, or methyl are disclosed. Processes of the invention begin with a starting material of the general formula IV ##STR2## wherein R.sup.1 and R.sup.2 are as defined in the specification.

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Kawai et al. "A Facile Synthesis of an Oxidation Product of Terfenadine" J. Or. Chem. 59, 2620-2622 (1994).
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