Synthesis of temozolomide and analogs

Organic compounds -- part of the class 532-570 series – Organic compounds – Four or more ring nitrogens in the bicyclo ring system

Reexamination Certificate

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C548S326500

Reexamination Certificate

active

06844434

ABSTRACT:
This invention relates to a novel process for the synthesis of temozolomide, an antitumor compound, and to intermediates useful in this novel process.

REFERENCES:
patent: 5260291 (1993-11-01), Lunt et al.
patent: 0 113 570 (1984-07-01), None
patent: 02 252 682 (1987-07-01), None
patent: 2 125 402 (1983-08-01), None
Wang, et al., “Alternative Syntheses of the antitumor drug temozolomide avoiding the use of methyl isocyanates”, Journal of Chemical Society, Chemical Communication, Chemical Society, Letchworth, GB, p. 1687-1688 (1994).
Wang, et al., “Antitumor imidazotetrazines. Part 33. new syntheses of the antitumor drug temozolomide using ‘masked’ methyl isocyanates”, J. Chem. Soc., Perkin Trans. 1(21):2783-2787 (1995).
Wang, et al., “Synthetic studies of 8-carbamoylimidzo-'5, 1-D!-1, 2, 3, 5-tetrazi n-4(3H)- one: a key derivative of antitumor drug temozolomide”, Bioorg. Med Chem. Lett., 6(2):185-188 (1996).
Yongfeng Wang, “A new route to the antitumor drug temozolomide, but not thiotemozolomide”, Chem. Commun., 4:363-364 (1997).
Wang, et al., “Antitumor Imidazotetrazines. 35. New Synthetic Routes to the Antitumor Drug Temozolomide”, J. org. Chem. 62(21):7228-7294 (1997).
Newlands, E.S., et al., “Temozolomide: a review of its discovery, chemical properties, pre-clinica development and clinical trials”, Cancer Treat. Rev. , 23(1):35-61 (1997).
Wang, et al., Antitumor Imidazotetrazines. Part 36. Conversion of 5-Amino-Imidazole-4-Carboxamide to . . . Journal of the Chemical Society, Perkin Transactions 1, Chemical Society, Letchworth, GB, 10:1669-1675 (1998).

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