Synthesis of substituted heterocyclic compounds

Details Synthesis of substituted heterocyclic compounds Synthesis of substituted heterocyclic compounds

2004-04-30

2010-11-23

Morris, Patricia L (Department: 1625)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C548S195000, C548S233000, C548S314700, C548S331500, C548S332500

Reexamination Certificate

active

07838681

ABSTRACT:
The invention relates to a method of synthesizing heterocyclic compounds. The invention is characterised in that it consists in opening a compound having formula (I), wherein: —X represents NH, O, S or a N-p group, p being a protective group, such as Boc or Troc; —Y represents N, O, S; —Z represents NH2or NH-p; and —R1represents a C1-C6alkoxy radical, aryloxy, such as phenyloxy, or a pyrrolyl radical, said radicals being optionally substituted, or the salts thereof, and the isomers of the aforementioned compounds. Moreover, the above-mentioned opening step is performed in conditions such as to produce a heterocycle having formula (II), wherein: —X, Y and Z are as defined above; —R2represents a —CH═CH—CH2—NH—COR1or —CH═CH—CH2—NH—CO group; and R3occupies one, two or three positions and represents a halogen. The invention can be used to synthesise natural products.

REFERENCES:
patent: 6441013 (2002-08-01), Greiner et al.
International Search Report for PCT/FR2004/001059 dated 8 Nov. 2004.

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