Synthesis of steroids

Details Synthesis of steroids Synthesis of steroids

1978-12-18

1980-08-12

Roberts, Elbert L.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

2603971, 2603975, 2603972, C07J 900, C07J 7100

Patent

active

042172799

ABSTRACT:
The synthesis of 25-hydroxycholesterol and 1.alpha.,25-dihydroxycholesterol in which the sterol nucleus of an ester of hyodeoxycholic acid is stabilized by protection of the 3 and 6.alpha.-hydroxyl groups with alkyl groups, alkyl ether groups, preferably with the 3.beta.-methoxyethoxymethyl group or with the heterocyclic 2-tetrahydropyran group, then extending the chain from the carbon at the 24-position to a cyanide group at the 25-position and then subjecting the sterol so formed to a series of reactions by which it is transformed into 1.alpha.,25-dihydroxycholesterol or by a modified series of reactions to 25-hydroxycholesterol.

REFERENCES:
patent: 3882254 (1974-07-01), Partridge, Jr. et al.
patent: 3887545 (1975-06-01), Iacobelli
patent: 4134904 (1979-01-01), Kaiser

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