Synthesis of SRS-active compounds

Details Synthesis of SRS-active compounds Synthesis of SRS-active compounds

1980-03-24

1982-01-19

Milestone, Norma S.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

546184, 560153, 562557, 568 59, 568448, 568597, 568873, 549 80, C07D30342, C07D30338

Patent

active

043116450

ABSTRACT:
A chemical synthesis of an SRS-A active compound from the reaction product of 1-halo-2-octyne and the ether of 2-penten-4-yn-1-ol including intermediates in the synthesis, some of which being antagonists of SRS-A useful for treating allergic reactions.

REFERENCES:
patent: 3882148 (1975-05-01), Augstein et al.
patent: 4174402 (1979-11-01), Mielens
M. Hitchcock, Jour. Pharm. and Experimental Therapeutics, vol. 207, No. 2, (1978) pp. 630-640.
S. Hammarstrom et al., Biochemical and Biophysical Communications, vol. 91, No. 4 (1979), pp. 1266-1272.
Jeffrey L. Fox, Science, vol. 57 (1979) p. 19.
E. J. Corey et al., Jour. Am. Chem. Soc., Oct. 24, 1979, vol. 101, No. 22, pp. 6748-6749.
Michael Rosenberger et al., J. Am. Chem. Soc., vol. 102, p. 5425 (1980).

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