Synthesis of specifically labeled tetrodotoxin

Details Synthesis of specifically labeled tetrodotoxin Synthesis of specifically labeled tetrodotoxin

1991-11-18

1994-02-22

Shah, Mukund J.

Organic compounds -- part of the class 532-570 series

Organic compounds

Four or more ring nitrogens in the bicyclo ring system

544330, C07D491052

Patent

active

052888703

ABSTRACT:
The present invention relates to a process for the preparation of specifically labelled TTX of high specific activity. In the present process, TTX is oxidized by use of the Pfitzer-Moffat method or Fenton's reagent and the aldehyde obtained is hydrated. The hydrated aldehyde is reduced with alkali metal o alkaline earth metal borotritide. The radioactive TTX so obtained, quite surprisingly, has a specific activity many times greater than previously prepared radioactive TTX.

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