Synthesis of single-stranded labelled oligonucleotides of presel

Details Synthesis of single-stranded labelled oligonucleotides of presel Synthesis of single-stranded labelled oligonucleotides of presel

1995-05-12

1997-09-16

LeGuyader, John L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 243, 536 2531, 536 2532, C07H 2100, C07H 2102, C07H 2104

Patent

active

056682662

ABSTRACT:
Substantially pure single-stranded oligonucleotides having a preselected sequence of not more than about 200 nucleotides, at least one of which is at a preselected position in the sequence and includes a base with a covalently attached linker arm containing or capable of binding at least one reporter group or solid support. A process for the chemical synthesis of the substantially pure single-stranded oligonucleotide and modified nucleosides useful in such synthesis are provided.

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