Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Reexamination Certificate
2011-07-19
2011-07-19
Balasubramanian, Venkataraman (Department: 1624)
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
C514S263100, C544S264000, C536S027600, C536S027810, C536S025300, C536S028540
Reexamination Certificate
active
07982030
ABSTRACT:
The present invention provides selenium derivatives of nucleosides, nucleoside phosphoramidites, nucleotides, nucleotide triphosphates, oligonucleotides, polynucleotides, and larger nucleic acids and methods for their synthesis. Selenium derivatives of both ribonucleic acids and deoxyribonucleic acids, as well as methods for their synthesis, crystallization and uses in structural determinations, particularly by X-ray crystallographic techniques are disclosed. The selenium derivatives of the present invention are also useful as food supplements.
REFERENCES:
patent: 3998806 (1976-12-01), Townsend
patent: 4536571 (1985-08-01), Stockel et al.
patent: 4552955 (1985-11-01), Takaku et al.
patent: 4617189 (1986-10-01), Stockel et al.
patent: 5166330 (1992-11-01), Engels et al.
patent: 5359052 (1994-10-01), Stee et al.
patent: 5449664 (1995-09-01), Verheyden et al.
patent: 5512668 (1996-04-01), Stec et al.
patent: 5700660 (1997-12-01), Leonard et al.
patent: 5856465 (1999-01-01), Stec et al.
patent: 5883237 (1999-03-01), Stec et al.
patent: 6348583 (2002-02-01), Segev
patent: WO 98/49179 (1998-11-01), None
Mautner et al. J. Med. Chem. 6, 36-39, 1963.
Chu et al. J. Med. Chem. 18, 559-564, 1975( Chu-1).
Chu et al. J. Med. Chem. 17, 406-409, 1974( Chu-2).
Adrian R. Ferré-D' Amaré, Kaihong Zhou and Jennifer A. Doudna, “Crystal structure of a hepatitis delta virus-ribozyme,”Nature(1998) 395:567-574.
Bollmark et al., Chemical Communications, 11, 991-992, 1997; CA 127:95522, 1997.
Choi et al., Journal of Medicinal Chemistry, 22(6), 618-621, 1979.
Helinski et al., Nucleosides & Nucleotides, 12(16), 597-604, 1993; CA 120: 31143, 1994.
Helinski et al., Phosphorous, Sulfur and Silicon and related Elements, 76(1-4), 395-398, 1993; CA 120: 192167, 1994.
Nemer et al., Tetrahedron Letters, 106(20), 21(43), 4153-4154, 1980.
Nemer et al., Tetrahedron Letters, 21(43), 4149-4152, 1980.
Quan Du, Nicolas Carrasco, Marianna Teplova, Christopher J. Wilds, Martin Egli, and Zhen Huang, “Internal Derivatization of Oligonucleotides with Selenium for X-ray Crystallography Using MAD”,J. Am. Chem. Soc. (2002) 124: 24-25.
Sekine et al., Chemistry Letters, (7), 801-802, 1979.
Shih-His Chu, Chyng-Yann Shiue, and Ming-Yu Chu, “Synthesis and Biological Activity of Some 8-Substituted Selenoguanosine Cyclic 3′,5′-Phosphates and Related Compounds,”Journal of Medicinal Chemistry(1975) 18: 559-564.
Stawinski et al., Tetrahedron Letters, 30(16), 2157-2160, 1989.
Stawinski et al., Tetrahedron Letters, 33(47), 7255-7258, 1992.
Stec et al., Journal of American Chemical Society, 106(20), 6077-66079, 1984.
Wei-Mei Ching, Birgit Alzner-DeWeerd, and Thressa C. Stadtman, “A selenium-containing nucleoside at the first position of the anticodon in seleno-tRNAGIufromClostridium stricklandii,” Proc. Natl. Acad. Sci. USA(1985) 82: 347-350.
Wozniak et al., Bioorganic & Medicinal Chemistry Letters, 4(8), 1033-1036, 1994.
Zsuzsa Veres, Lin Tsai, Thomas D. Scholz, Michael Zpolitino, Robert S. Balaban, and Thressa C. Stadtman, “Synthesis of 5-methylaminomethy1-2-selenouridine in tRNAs:31P NMR studies show the liable selenium donor synthesized by these/D gene product contains selenium bonded to phosphorus,”Proc. Natl. Acad. Sci. USA(1992) 89: 2975-2979.
Balasubramanian Venkataraman
Georgia State University Research Foundation, Inc.
Sutherland & Asbill & Brennan LLP
LandOfFree
Synthesis of selenium-derivatized nucleosides, nucleotides,... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Synthesis of selenium-derivatized nucleosides, nucleotides,..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Synthesis of selenium-derivatized nucleosides, nucleotides,... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2694548