Synthesis of scabronines and analogues thereof

Details Synthesis of scabronines and analogues thereof Synthesis of scabronines and analogues thereof

2011-03-22

2011-03-22

Shiao, Rei-tsang (Department: 1628)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Ester doai

C560S117000, C562S499000

Reexamination Certificate

active

07910623

ABSTRACT:
A novel synthesis of scabronines, which are related to a broader class of angularly fused tricyclic diterpenoids known as cyathanes, is provided. Scabronine G, its methyl ester derivative, and other analogs have been shown to have neurotrophic activity. Therefore, these compounds are particularly useful in treating neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, Huntington's diseases, etc. The invention provides for the synthesis of scabronines as well as analogs thereof. Pharmaceutical compositions and method of using the inventive compounds are also provided.

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