Synthesis of (S)-.alpha.-methyl-1,3-benzodioxole-5-ethanol and d

Details Synthesis of (S)-.alpha.-methyl-1,3-benzodioxole-5-ethanol and d Synthesis of (S)-.alpha.-methyl-1,3-benzodioxole-5-ethanol and d

1999-07-02

2000-12-12

McKane, Joseph K.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

435123, C07D31754

Patent

active

061601330

ABSTRACT:
A process for stereoselectively forming N-substituted dihydro-2,3 benzodiazepines which are useful as AMPA receptor antagonists. The process includes an opening reduction step which sets the stereochemistry of the intermediates and the final compounds to the desired enantiomer. The reduction step may be carried out by an enzymatic reduction.

REFERENCES:
patent: 4247560 (1981-01-01), Mues et al.
Caldwell, Modern Drug Discovery, pp. 51-60, 1999.
Kim et. al., J. Org. Chem. 1993, 58, 4511-4512.
T. Lang, et al., Chemical Abstracts, vol. 105, No. 25, Dec. 11, 1986, abstract No. 226357v.

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