Synthesis of quinone pyrano-gamma-lactone antibiotics and antifu

Details Synthesis of quinone pyrano-gamma-lactone antibiotics and antifu Synthesis of quinone pyrano-gamma-lactone antibiotics and antifu

1979-05-25

1980-12-02

Jiles, Henry R.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

2603478, C07D49304

Patent

active

042370574

ABSTRACT:
An efficient synthesis of quinone pyrano-gamma-lactone antibiotics such as kalafungin and the new compound 9-deoxykalafungin in four basic steps from readily available starting materials. The key step in which all of the carbon atoms present in the target molecule are assembled is the addition of an alkoxy furan to a two position functionally substituted 1,4 naphthoquinone. This is followed by alkylating to provide protecting groups, hydride reduction, removal of the protecting groups, internal cyclization and by oxidative dealkylation to provide practical overall yields of the desired antibiotics.

REFERENCES:
Omura et al. Jour. Chem. Soc. Chem. Comm. pp. 320-321, 1976.
Bergy The Journ. of Antibiotics 21, Jul. 1969, pp. 454-457.

Affiliated with

Also associated with

Rating

Synthesis of quinone pyrano-gamma-lactone antibiotics and antifu does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Synthesis of quinone pyrano-gamma-lactone antibiotics and antifu, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Synthesis of quinone pyrano-gamma-lactone antibiotics and antifu will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2283373