Synthesis of purine substituted cyclopentene derivatives

Details Synthesis of purine substituted cyclopentene derivatives Synthesis of purine substituted cyclopentene derivatives

1990-04-06

1992-06-30

Rivers, Diana G.

Organic compounds -- part of the class 532-570 series

Organic compounds

Chalcogen bonded directly to ring carbon of the purine ring...

544277, 558260, 558265, 560231, 568659, 568838, C07D47318, C07D47340

Patent

active

051264528

ABSTRACT:
This invention relates to new process for preparing certain optically active purine substituted cyclopentene derivatives and novel intermediates used in this process. In particular, the invention concerns the synthesis of the 1R-cis isomer of carbovir, (1R-cis)-amino-1,9-dihydro-9-[4-(hydroxymethyl)-2-cyclopenten-1-yl]-6H-pur in-6-one, an antiviral agent, and certain intermediates.

REFERENCES:
patent: 4916224 (1990-04-01), Vince et al.
patent: 4931559 (1990-06-01), Vince et al.
patent: 4950758 (1990-08-01), Vince et al.
patent: 4968674 (1990-11-01), Taniyama et al.
patent: 4999428 (1991-03-01), Saksena et al.
patent: 5015739 (1991-05-01), Saksena et al.
patent: 5034394 (1991-07-01), Daluge
McOmie, "Protective Groups in Organic Chemistry", Plenum Press, London and New York (1973), pp. 100-103 and 114-117.
Greene, "Protective Groups in Organic Synthesis", John Wiley & Sons, New York, (1981), pp. 34-37 and 64-69.
Marquez, et al., Nucleosides and Nucleotides, vol. 6 (1 & 2), pp. 239-244 (1987).
Tsuji, Tetrahedron, vol. 42, No. 16, pp. 4361-4401 (1986).
March, J., Advanced Organic Chemistry, 3rd Ed., Chap. 4 John Wiley & Sons, New York, N.Y. (1985).
Vince, R., et al., Biochem. Biophys. Res. Commun. 156 (2) 1046 (1988).
Trost, et al., J. Am. Chem. Soc., 110, 621 (1988).
Synthesis, Sugai, T., et al., 19-22 (1988).

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