Synthesis of protease inhibitor

Details Synthesis of protease inhibitor Synthesis of protease inhibitor

1992-02-27

1993-03-09

Cashion, Jr., Merrell C.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

435 711, 435120, 4352535, 544 60, C12P 100, C12P 2104

Patent

active

051926687

ABSTRACT:
A dipeptide isostere is the biotransformed product after incubation with a culture of Streptomyces. It inhibits HIV protease, and is useful in the prevention or treatment of infection by HIV and the treatment of AIDS, either as a compound, pharmaceutically acceptable salt, pharmaceutical composition ingredient, whether or not as a prodrug or as a combination with other antivirals, anti-infectives, immunomodulators, antibiotics or vaccines. Methods of treating AIDS and methods of preventing or treating infection by HIV are also described.

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