Synthesis of polysaccharide covered superparamagnetic oxide coll

Details Synthesis of polysaccharide covered superparamagnetic oxide coll Synthesis of polysaccharide covered superparamagnetic oxide coll

1991-05-02

1993-11-16

Hollrah, Glennon H.

Drug, bio-affecting and body treating compositions

In vivo diagnosis or in vivo testing

Magnetic imaging agent

42721333, 1286534, 128654, 600 12, 424646, 648403, 648407, G01N 2408, B01J 1302, A61M 3700, A61K 3326

Patent

active

052621766

ABSTRACT:
In a method for the synthesis of a colloid including a superparamagnetic metal oxide coated with a polymer, an acidic solution of a metal salt and a polymer may be cooled, and then neutralized by the controlled addition of a cool solution of a base, and may then be converted, by the application of heat, to a homogenous superparamagnetic metal oxide colloid. According to a preferred embodiment, the polymer may be a polysaccharide. In a further embodiment of the invention, the polysaccharide may be dextran and the metal salt may be ferrous and ferric salts, which produces, according to the methods of the invention, a superparamagnetic iron oxide colloid with an extended plasma half-life.

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