Synthesis of polyribosylribitol phosphate oligosaccharides

Details Synthesis of polyribosylribitol phosphate oligosaccharides Synthesis of polyribosylribitol phosphate oligosaccharides

1995-06-07

1999-10-26

Marschel, Ardin H.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

4241841, 4241931, 4241941, 424280, 514 23, 514 25, 514 54, 514 75, 514 99, 514109, 514112, 514120, 514125, 514129, 514139, 514143, 514183, 514506, 536 111, 536 41, 536 187, 536117, 5361231, 536126, 536127, A61K 39102

Patent

active

059723491

ABSTRACT:
Polyribosylribitol phosphate oligosaccharides are produced in a multistep process. The compound of the formula: ##STR1## wherein R.sub.1 is a first protecting group and R.sub.2 is a second protecting group, is coupled to a solid polyethylene glycol monomethyl ether (PEG) support. Following removal of the first protecting group, the resulting compound is coupled with a repeating unit for chain elongation of the formula: ##STR2## The protecting group is removed from the phosphorus atom and the steps of removing the first protecting group, coupling with the repeating unit is repeated until the desired number of repeating units in the oligomer has been terminated. The oligomer then is terminated with a chain terminating molecule of the formula: ##STR3## wherein m is an integer and R.sub.3 is a third protecting group. The resulting PEG-bound protected oligomer is a new product and the oligomer may be cleaved from the support and processed to provide a chemically-reactive functional group for binding the polysaccharide oligomer to a carrier molecule.

REFERENCES:
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