Synthesis of podophyllotoxin derivatives

Details Synthesis of podophyllotoxin derivatives Synthesis of podophyllotoxin derivatives

1986-12-15

1990-02-13

Griffin, Ronald W.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 41, 536 185, 536 186, 536124, C07H 1524

Patent

active

049008145

ABSTRACT:
There is provided a novel process for the production of the epipodophyllotoxin glycosides, Etoposide and Teniposide. There are further provided certain novel 4'-demethylepipodophyllotoxin derivatives of the following formula ##STR1## where W is hydrogen or 2,3-di-O-acetyl-4,6,O-ethylidene-D-glucopyran-1-yl. These intermediates are easily transformed into Etoposide and Teniposide and into further derivatives of this series.

REFERENCES:
patent: 4564675 (1986-01-01), Kurabayashi et al.
patent: 4609644 (1986-09-01), Nemec
patent: 4757138 (1988-07-01), Fujii et al.

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