Synthesis of piperidine and piperazine compounds as CCR5...

Details Synthesis of piperidine and piperazine compounds as CCR5... Synthesis of piperidine and piperazine compounds as CCR5...

2006-01-31

2006-01-31

Chang, Celia (Department: 1625)

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

C544S229000, C544S360000, C544S364000, C514S252180, C514S253010, C514S253110, C514S253100, C514S253090

Reexamination Certificate

active

06992189

ABSTRACT:
In its several embodiments, this invention discloses novel processes to prepare the compounds of formula II and formula IV:

REFERENCES:
patent: 6391865 (2002-05-01), Baroudy et al.
patent: 2003/0144510 (2003-07-01), Gala et al.
patent: WO 00/66559 (2002-08-01), None
patent: WO 02/66558 (2002-08-01), None
patent: WO 03/33490 (2003-04-01), None
A. Palani et al., “Discovery of 4-[(Z)-4Bromophenyl)-(ethoxyimino)methyl]-1′-[(2,4-dimethyl-3-pyridinyl)carbonyl]-4′-methyl-1,4′bipiperidine N-Oxide (SCH 351125): An Orally Bioavailable Human CCR5 Antagonist for the Treatment of HIV Infection”,J. Med. Chem., 44(21): 339-3342 (2001).
R. de Weerd et al., “A New Class of Chiral Detergents. The Formation of Single Micelles from N.N-Dimethyl-1-dodecyl-2,4-dimethyl-3-carbamoylpyridinium Bromide. A CD Study”,J. Org. Chem., 49: 3413-3415 (1984).
T. J. Kress, “Synthesis and Proton NMR Spectra of the Monomethyl- and Dimethylpyrimidine-5-Carboxylic Acids. Regioselective Covalent Hydration at the 2- and 4- Ring Positions”,Heterocycles38(6): 1375-1382 (1994).

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