Synthesis of piperazine ring

Details Synthesis of piperazine ring Synthesis of piperazine ring

2005-02-08

2005-02-08

Bernhardt, Emily (Department: 1624)

Organic compounds -- part of the class 532-570 series

Organic compounds

Unsubstituted hydrocarbyl chain between the ring and the -c-...

C544S360000, C544S383000, C544S384000, C544S391000

Reexamination Certificate

active

06852855

ABSTRACT:
A novel process for preparing a compound of the formula I:whereinR1denotes substituted or unsubstituted alkyl, alkoxy, aryl, aryloxy or arylalkoxy; R2denotes substituted or unsubstituted alkyl, alkoxy, aryl, aryloxy, arylalkoxy, tosyl, formyl, acetyl or amine; and R3denotes substituted or unsubstituted alkyl, alkoxy, aryl, aryloxy or arylalkoxy is disclosed. These compounds are useful in the synthesis of the antidepressant mirtazapine and other tetracyclic compounds.

REFERENCES:
patent: 2507408 (1950-05-01), Jacob
patent: 2830056 (1958-04-01), Ruschig et al.
patent: 2891063 (1959-06-01), Sommers
patent: 3663548 (1972-05-01), Nitta et al.
patent: 4025513 (1977-05-01), Olivie
patent: 4062848 (1977-12-01), van der Burg
patent: 4217452 (1980-08-01), Olivie
patent: 4912110 (1990-03-01), Lafon
patent: 4918190 (1990-04-01), Toda et al.
patent: 4935515 (1990-06-01), Winkley et al.
patent: 6339156 (2002-01-01), Dolitzky
patent: 174 215 (1979-11-01), None
Nickolson et al., J. Pharm. Pharmacol. 33, pp. 760-766 (1981).*
Nishimura et al., Chem. Pharm.Bull., vol. 17, p94-97 (1969).*
Roderick, W.R. et al., J. Med. Chem, 1966, vol. 9, pp. 181-185.
Database Crossfire Beilstein Online! Beilstein Institut zur Forderung der Chemischen Wissenschaften, Frankfurt am Main, DE; Database accession No. 1584167 XP002196248 1-p-Toluolsulfonyl-2, 4-dimethyl-piperazine * abstract* for Chem Pharm Bull, vol. 17, No. 1, 1969, p. 94ff, Nishimura.
Fujimura et al: “Synthesis, Structure and quantitative Structure-Activity Relationships of sigma receptor Ligands, 1-2-(3,4-Dimethoxyphenyl)ethyl !-4-(3-phenylpropyl)piperazines” Bioorganic & Medicinal Chemistry, vol. 5, No. 8, 1997, pp. 1675-1683, XP002196245 Reaction of 4 and 5 on *p. 1676*.
Chemical Abstracts, vol. 71, No. 21, Nov. 24, 1969 Columbus, Ohio, US; abstract No. 101885, Nitta, Yoshihiro et al: “Piperazine derivatives and their salts” XP002196247 *abstract* & JP 44 018306 B (Chugai Pharmaceutical Co., Ltd.) Aug. 11, 1969.

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