Synthesis of photolabile chelators for multivalent cations

Details Synthesis of photolabile chelators for multivalent cations Synthesis of photolabile chelators for multivalent cations

1987-10-20

1991-01-01

Lander, Ferris H.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heavy metal containing

556134, 556148, 558 44, 562435, C07F 1300

Patent

active

049819852

ABSTRACT:
A method of synthesizing photolabile chelators as EDTA and EGTA derivatives to be used in caging multivalent cations is disclosed. The chelators chelate the cations forming non-biologically active compounds. The chelated compounds can then be localized in or near biological systems. Upon irradiation, the chelated compound cleaves with the subsequent cleaved remainders having a substantially lower affinity for the chelated cation. Large amounts of cation are thus rapidly released and the effect of such concentration jumps on the biological system can be accurately studied.

REFERENCES:
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