Synthesis of peptides with parathyroid hormone activity

Details Synthesis of peptides with parathyroid hormone activity Synthesis of peptides with parathyroid hormone activity

1975-02-10

1978-08-08

Phillips, Delbert R.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

2601125R, C08L 3700, C07C10352

Patent

active

041056027

ABSTRACT:
Resin peptides useful in the preparation of peptides having biological activity, and particularly such resin peptides containing R--CH.sub.2 --O--Phe--Asn at one end of an amino acid chain, R being the resin and Phe and Asn being the residues of the amino acids phenylalanine and asparagine; and processes for the preparation of such resin peptides. Resin peptides are disclosed which contain amino acid chains identical with the amino acid chains of natural peptides having biological activity. Other resin peptides are disclosed which contain amino acid chains in which the amino acid residues differ in kind and sequence from amino acid chains of natural biologically active peptides but from which peptides having biological acitivity may be derived.

REFERENCES:
patent: 3886132 (1975-05-01), Brewer et al.
patent: 3912711 (1975-10-01), Leeman et al.
patent: 3917579 (1975-11-01), Bumpus et al.
patent: 3987014 (1976-10-01), Guiducci et al.
patent: 3988307 (1976-10-01), Gross
patent: 4002740 (1977-01-01), Goldstein et al.
patent: 4022760 (1977-05-01), Tinney
J. M. Stewart et al., "Solid Phase Peptide Synthesis", 1969, pp. 1-18.
Merrifield, Adv. in Enzymology, 32, 243-251 (1969).
Sakakibara et al.: Bull. Chem. Soc., Japan, 42, 1466 (1969).
Haslam, "Protective Groups in Organic Chemistry", J. McOmie, ed., Plenum Press, London, 1973, pp. 196-198.

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