Synthesis of peptide analogs

Details Synthesis of peptide analogs Synthesis of peptide analogs

1987-03-11

1988-12-27

Kight, John

Synthetic resins or natural rubbers -- part of the class 520 ser

Synthetic resins

Mixing of two or more solid polymers; mixing of solid...

530334, A61K 3702, C07C10352, C08F28300

Patent

active

047941502

ABSTRACT:
A novel polymeric disc, wafer or similarly shaped resin for carrying out the synthsis of peptide analogs via solid phase peptide synthesis techniques is provided. The polymeric disc or wafer of the invention may be made out of those resin materials presently used in bead form in solid phase peptide synthesis, such as, benzhydrylamine resins, Boc-aminoacyl-4-(oxymethyl)-phenyacetamidomethyl (Pam) resin, polyamide resins and chloromethyl resins. The disc or wafer of the invention should, preferably, have a thickness of 200-400 .mu.m and may be of any suitable length or width. A process for the synthsis of peptide analogs utilizing the polymeric disc or wafer of the present invention is also disclosed.

REFERENCES:
patent: 4410660 (1983-10-01), Straw
patent: 4517338 (1985-05-01), Urdea et al.
patent: 4569967 (1986-02-01), Kornreich et al.
patent: 4626581 (1986-12-01), Weigel
patent: 4631211 (1986-12-01), Houghten
Matthes et al. (1984) The EMBO Journal, 3, 801-805.
Geysen et. al. (1984) Proc. Natl. Acad. Sci. USA, 81, 3998-4002.
Kent et. al., Modern Methods for Chemical Synthesis . . . Cal. In. Tech.
Houghten, R. A. (1985) Proc. Natl. Acad. Sci. USA 82, 5131-5135.

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