Synthesis of peptide aminoalkylamides and peptide hydrazides by

Details Synthesis of peptide aminoalkylamides and peptide hydrazides by Synthesis of peptide aminoalkylamides and peptide hydrazides by

1994-06-08

1996-10-15

Shippen, Michael L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acid esters

530326, 546335, 560 23, 560 26, 560 32, 560 55, 560 61, 560 66, 560159, C07C26100

Patent

active

055656064

ABSTRACT:
The invention relates to compounds of the formula I ##STR1## in which A denotes hydrogen or an amino protective group, B denotes one or more amino acids, X denotes alkylene or aralkylene, Y.sup.1, Y.sup.2, Y.sup.3 and Y.sup.4 are identical or different and denote hydrogen, methyl, methoxy or nitro, V denotes hydrogen or a carboxyl protective group, W denotes --[CH.sub.2 ].sub.n -- or --O--[CH.sub.2 ].sub.n --, m denotes 0 or 1, n denotes 0 to 6, and p denotes 0 to 5, to a process for their preparation. The compounds of formula I are useful as linkage agents or anchor groups in the solid-phase synthesis of peptide aminoalkylamides and peptide hydrazides.

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