Synthesis of peptide amides

Details Synthesis of peptide amides Synthesis of peptide amides

1976-03-31

1978-05-16

Phillips, Delbert R.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

2601125R, 424177, C08L 3700, C07C10352, A61K 3700

Patent

active

040898210

ABSTRACT:
Peptide amides having biological activity and resin peptide amides useful in the preparation of peptides having biological activity, particularly such peptides containing the structure ##STR1## in which R is divinylbenzene crosslinked polystyrene and Bz is benzyl, p-methoxybenzyl, p-chlorobenzyl, p-nitrobenzyl, or benzhydryl, and in which phe and glu are residues of the amino acids phenylalanine and glutamic acid; and processes for preparing such peptide amides.
Resin peptide amides are disclosed which contain amino acid chains identical with the amino acid chains of natural peptides having biological activity. Other resin peptide amides are disclosed which contain amino acid chains in which the amino acid residues differ in kind or sequence from amino acid chains of natural biologically active peptides but from which peptides having biological activity may be derived.

REFERENCES:
patent: 3388112 (1968-06-01), Geiger et al.
patent: 3483291 (1969-12-01), Vogel et al.
patent: 3651039 (1972-03-01), Fujino et al.
patent: 3749704 (1973-07-01), Geiger et al.
patent: 3759891 (1973-09-01), Otsuka et al.
patent: 3761459 (1973-09-01), Pless et al.
patent: 3761461 (1973-09-01), Pless et al.
patent: 4001199 (1977-01-01), Fujino et al.
R. L. Colescott, et al.; Chem. Abst. 85, p. 177917k.
Pietta et al., J. Org. Chem., 39, 44-48 (1974).

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