Synthesis of penta-substituted guanidines

Details Synthesis of penta-substituted guanidines Synthesis of penta-substituted guanidines

1994-09-12

1997-12-09

O'Sullivan, Peter

Organic compounds -- part of the class 532-570 series

Organic compounds

Amino nitrogen containing

564230, 564237, 564239, 564240, C07C27708

Patent

active

056962908

ABSTRACT:
The present invention is the novel synthesis of sterically hindered penta-substituted guanidines by a process in which (1a) an isocyanate is reacted first with a di-substituted amine or (1b) a urea is reacted with two moles of a mono-substituted amine to form a tri-substituted urea followed by (2) treatment of the tri-substituted urea with an activating agent before reacting with a second di-substituted amine in the presence of a base.

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