Synthesis of optically pure 4-aryl-2-hydroxytetronic acids

Details Synthesis of optically pure 4-aryl-2-hydroxytetronic acids Synthesis of optically pure 4-aryl-2-hydroxytetronic acids

1994-02-25

1995-03-21

Raymond, Richard L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

549 60, 549316, C07D30762

Patent

active

053997212

ABSTRACT:
The present invention relates to a method for synthesis of optically pure stereogenically labile 4-aryl-2-hydroxytetronic acids from an optically pure aldehyde. The invention further relates to the use of such optically pure compounds as potent inhibitors of platelet aggregation by working at the level of cyclooxygenase. the invention further relates to the pharmaceutical use of such compounds in the treatment of coronary artery diseases, especially in the treatment and/or prevention of atherosclerosis.

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