Synthesis of optically active phenylalanine analogs using Rhodot

Details Synthesis of optically active phenylalanine analogs using Rhodot Synthesis of optically active phenylalanine analogs using Rhodot

1997-09-24

1999-11-09

Saucier, Sandra E.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing alpha or beta amino acid or substituted amino acid...

435280, C12P 1322, C12P 4100

Patent

active

059812397

ABSTRACT:
A biocatalytic process to produce optically active phenylalanine analogs from arylacrylic acids is disclosed in which Rhodotorula graminis yeast containing phenylalanine ammonia-lyase introduces a molecule of ammonia stereoselectively onto the double bond of a 3-substituted acrylic acid. The substituent at the 3-position of the 3-substituted acrylic acid includes, for example, aromatic rings such as substituted phenyl groups, five member aromatic heterocyclics, and six member aromatic heterocyclics.

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