Synthesis of oligonucleotides with boranophosphonate linkages

Details Synthesis of oligonucleotides with boranophosphonate linkages Synthesis of oligonucleotides with boranophosphonate linkages

1996-09-16

1999-01-12

Zitomer, Stephanie W.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 245, C07H 2104

Patent

active

058592318

ABSTRACT:
The present invention relates, in general, to a process of enzymatically synthesizing nucleic acids containing boranophosphonate linkages that are resistant to degradation. The invention further relates to methods of utilizing such nucleic acids in DNA and RNA amplification and sequencing, gene therapy and molecular detection protocols.

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Mundy, WO 86/07612 Abstract.

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