Synthesis of oligonucleotides containing alkylphosphonate intern

Details Synthesis of oligonucleotides containing alkylphosphonate intern Synthesis of oligonucleotides containing alkylphosphonate intern

1996-02-26

1999-10-05

Wilson, James O.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 253, 536 2531, 536 2533, 536 231, C07H 2100

Patent

active

059626747

ABSTRACT:
The invention provides new reagents and an improved process for synthesizing oligonucleotides that contain methylphosphonate internucleoside linkages. The reagents and process utilize a nucleoside base protecting group that is stable under oligonucleotide synthesis conditions, but which can be removed under more mild conditions than existing protecting groups.

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