Synthesis of oligonucleotide analogs

Details Synthesis of oligonucleotide analogs Synthesis of oligonucleotide analogs

1988-12-23

1991-08-06

Nutter, Nathan M.

Synthetic resins or natural rubbers -- part of the class 520 ser

Synthetic resins

Mixing of two or more solid polymers; mixing of solid...

530333, 530334, 422131, 422134, C08F28300, C08G 6348, C08G 6391

Patent

active

050378821

ABSTRACT:
A novel polymeric support is provided for carrying out the synthesis of oligonucleotide analogs via solid-phase synthesis techniques. The suitably-shaped polymeric disc, wafer, etc., of the invention may be made of polystyrene, silica gel, glass beads, polyamide/kieselguhr, cellulose, etc. The suitably-shaped disc or wafer of the invention should, preferably, have a thickness of 200-400 .mu.m and may be of any suitable length or width. A process for the synthesis of oligonucleotide analogs utilizing the polymeric support of the present invention is also disclosed.

REFERENCES:
patent: 3814732 (1974-06-01), Wang
patent: 4517338 (1985-05-01), Urdea et al.
patent: 4638032 (1987-01-01), Benner

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