Synthesis of nicotinamide cofactors

Details Synthesis of nicotinamide cofactors Synthesis of nicotinamide cofactors

1981-09-28

1983-10-25

Naff, David M.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing compound containing saccharide radical

435 89, 435177, 435180, 536 26, 536 27, C12P 1936, C12N 1108, C07H 1512, C07H 1900

Patent

active

044119950

ABSTRACT:
Nicotinamide cofactors are prepared in a process of reacting ribose -5- phosphate with a basic material selected from the group consisting of ammonia, primary and secondary amines in a polar non-aqueous solvent, reacting the resultant 1-ribosylamine -5- phosphate with a pyridinium salt and reacting the resultant nicotinamide mononucleotide with adenosine triphosphate in the presence of nicotinamide adenine dinucleotide pyrophosphorase to produce nicotinamide adenine dinucleotide which can be used directly in crude form without further purification in co-factor - requiring enzymatic reactions. The nicotinamide adenine dinucleotide pyrophosphorase may be immobilized on a solid support.

REFERENCES:
Walt, et al., Synthesis of Nicotinamide Adenine Dinucleotide (NAD) from Adanosine Monophosphate (AMP), J. Am. Chem. Soc., vol. 102, 1980 (pp. 7805-7806).
Tipson, R. S., Acetylation of D-Ribosylamine, J. Org. Chem., vol. 26, 1961 (pp. 2462-2464).

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