Synthesis of N,N-dimethyl-3-(4-methyl) benzoyl propionamide...

Details Synthesis of N,N-dimethyl-3-(4-methyl) benzoyl propionamide... Synthesis of N,N-dimethyl-3-(4-methyl) benzoyl propionamide...

2005-07-26

2005-07-26

Davis, Brian (Department: 1621)

Organic compounds -- part of the class 532-570 series

Organic compounds

Amino nitrogen containing

Reexamination Certificate

active

06921839

ABSTRACT:
The present invention relates to an improved and industrially advantageous process for the preparation of N,N-dimethyl-3-(4-methyl)benzoyl propionamide of Formula I,which is a key intermediate in the synthesis of zolpidem hemitartrate, a non-benzodiazepine hypnotic agent. The process includes reacting 3-(4-methyl)-benzoyl propionic acid of Formula IV, with alkyl chloroformate or pivaloyl chloride to get a mixed anhydride of Formula V; and reacting the mixed anhydride of Formula V with dimethylamine of Formula VI to get the N,N-dimethyl-3-(4-methyl)benzoyl propionamide of Formula I.

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