Organic compounds -- part of the class 532-570 series – Organic compounds – Heavy metal containing
Patent
1992-06-25
1995-02-28
Dees, Jose G.
Organic compounds -- part of the class 532-570 series
Organic compounds
Heavy metal containing
556107, 562446, C07F 722, C07C22900
Patent
active
053939085
ABSTRACT:
A protected 6-trimethylstannyl dopa derivative has been synthesized for the as a precursor for the preparation of 6-[.sup.18 F]fluoro-L-dopa. The tin derivative readily reacts with electrophilic radiofluorinating agents such as [.sup.18 F]F.sub.2, [.sup.18 F]OF.sub.2 and [.sup.18 F]AcOF. The [.sup.18 F]fluoro intermediate was easily hydrolyzed with HBr and the product 6-[.sup.18 F]fluoro-L-dopa was isolated after HPLC purification in a maximum radiochemical yield of 23%, ready for human use.
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Barrio Jorge R.
Bishop Allyson J.
Namavari Mohammad
Satyamurthy Nagichettiar
Dees Jos,e G.
Nazario Porfirio
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